Publications

PUBLICATIONS

Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome

Pearl A*, Bootz H*, Melzer E*, Sharon E*, Abuchatzera S, Amidror S, Aretz E, Shoval I, Yaron O, Malnick S, Yissachar N 
bioRxiv 2021

 
 
 

A Gut-Ex-Vivo System to Study Gut Inflammation Associated to Inflammatory Bowel Disease (IBD)

Gagliardi M, Monzani R, Clemente N, Fusaro L, Saverio V, Grieco G, Pańczyszyn E, Yissachar N, Boccafoschi F, Corazzari M.

Biology 2021

 
 

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Azriel S*, Bootz H*, Shemesh A*, Amidror S, Yissachar N.

J Vis Exp. 2021

 
 

Gut-Ex-Vivo system as a model to study gluten response in celiac disease

 

Gagliardi M, Clemente N, Monzani R, Fusaro L, Ferrari E, Saverio V, Grieco G, Pańczyszyn E, Carton F, Santoro C, Del Mare-Roumani S, Amidror S, Yissachar N, Boccafoschi F, Zucchelli S, Corazzari M

Cell Death Discov. 2021

 
 

High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function

 

Grosheva I, Zheng D, Levy M, Polansky O, Lichtenstein A, Golani O, Dori-Bachash M, Moresi C, Shapiro H, Del Mare-Roumani S, Valdes-Mas R, He Y, Karbi H, Chen M, Harmelin A, Straussman R, Yissachar N, Elinav E, Geiger B.

Gastroenterology 2020

 
 

β-arrestin 2 quenches TLR signaling to facilitate the immune evasion of EPEC.

 

Chen Z, Zhou R, Zhang Y, Hao D, Wang Y, Huang S, Liu N, Xia C, Yissachar N, Huang F, Chu Y, Yan D.

Gut Microbes 2020

 

Propionic acid shapes the course of multiple sclerosis by a distinct immunomodulatory mechanism

Duscha A*, Gisevius B*, Hirschberg S*, Yissachar N*, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, and Haghikia A. 

Cell 2020 

* Denotes equal contribution

Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks

Yissachar N.

Curr Opin Neurobiol. 2020

 
 

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk

Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D and Benoist C. 

Cell 2017

 
 

This work was recommended by the Faculty of 1000 (2017)

This work was highlighted by Ivanov, Trends in Immunology (2017)

This work was highlighted by Thomas, Nature Reviews Gastroenterology and Hepatology (2017)

Dynamic response diversity of NFAT isoforms in individual living cells.

Yissachar N*, Sharar Fischler T*, Cohen AA, Reich-Zeliger S, Russ D, Shifrut E, Porat Z, Friedman N.

Molecular Cell 2013

* Denotes equal contribution

 

Chromatin conformation governs T-cell receptor Jβ gene segment usage.

Ndifon W, Gal H, Shifrut E, Aharoni R, Yissachar N, Waysbort N, Reich-Zeliger S, Arnon R, Friedman N. 

Proc Natl Acad Sci U S A 2012

 
 

Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.

Salem H*, Rachmin I*, Yissachar N*, Cohen S, Amiel A, Haffner R, Lavi L, Motro B. 

Oncogene 2010

* Denotes equal contribution

 

Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated.

Noy-Lotan S, Dgany O, Lahmi R, Marcoux N, Krasnov T, Yissachar N, Ginsberg D, Motro B, Resnitzky P, Yaniv I, Kupfer GM, Tamary H. 

Haematologica 2009

 
 

Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.

Yissachar N, Salem H, Tennenbaum T, Motro B.

FEBS Lett. 2006

 
 

Nek1 shares structural and functional similarities with NIMA kinase

 

Feige E, Shalom O, Tsuriel S, Yissachar N, Motro B. Biochim Biophys Acta.

Biochimica et Biophysica Acta (BBA) 2006