High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function

Grosheva I, Zheng D, Levy M, Polansky O, Lichtenstein A, Golani O, Dori-Bachash M, Moresi C, Shapiro H, Del Mare-Roumani S, Valdes-Mas R, He Y, Karbi H, Chen M, Harmelin A, Straussman R, Yissachar N, Elinav E, and Geiger B. 

Gastroenterology (2020)

β-arrestin 2 quenches TLR signaling to facilitate the immune evasion of EPEC

Chen Z, Zhou R, Zhang Y, Hao D, Wang Y, Huang S, Liu N, Xia C, Yissachar N, Huang F, Chu Y, Yan D.

Gut Microbes (2020)

Propionic acid shapes the course of multiple sclerosis by a distinct immunomodulatory mechanism

Duscha A*, Gisevius B*, Hirschberg S*, Yissachar N*, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, and Haghikia A. 

Cell (2020) 

Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk

Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D and Benoist C. 

Cell (2017)

This work was recommended by the Faculty of 1000 (2017)

This work was highlighted by Ivanov, Trends in Immunology (2017)

This work was highlighted by Thomas, Nature Reviews Gastroenterology and Hepatology (2017)

Dynamic response diversity of NFAT isoforms in individual living cells


Yissachar N*, Sharar-Fischler T*, Cohen AA, Reich-Zeliger S, Russ D, Shifrut E, Porat Z and Friedman N. 

Molecular Cell. 2013 

This work was highlighted by Kalo and Shav-Tal, Genome Biology 2013 Jan 24;14(1):102


Chromatin conformation governs T-cell receptor Jβ gene segment usage.

Ndifon W, Gal H, Shifrut E, Aharoni R, Yissachar N, Waysbort N, Reich-Zeliger S, Arnon R, Friedman N. 

Proc Natl Acad Sci U S A (2012)

Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.

Salem H*, Rachmin I*, Yissachar N*, Cohen S, Amiel A, Haffner R, Lavi L, Motro B. 

Oncogene (2010)


* Denotes equal contribution

Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated.

Noy-Lotan S, Dgany O, Lahmi R, Marcoux N, Krasnov T, Yissachar N, Ginsberg D, Motro B, Resnitzky P, Yaniv I, Kupfer GM, Tamary H. 

Haematologica (2009) 

Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.

Yissachar N, Salem H, Tennenbaum T, Motro B.

FEBS Lett. (2006) 

Nek1 shares structural and functional similarities with NIMA kinase

Feige E, Shalom O, Tsuriel S, Yissachar N, Motro B. Biochim Biophys Acta.

Biochimica et Biophysica Acta (BBA) (2006)