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Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome

Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics

Hadar Bootz-Maoz, Azriel Simon, Sara Del Mare-Roumani, Yifat Bennet , Einat Toister, Hadar Romano, Danping Zheng, Sivan Amidror, Eran Elinav and Nissan Yissachar.
npj biofilms and microbiomes 2023


Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome

Bootz-Maoz H*, Pearl A*, Melzer E*, Malnick S*, Sharon E, Bennet Y, Tsentsarevsky R, Abuchatzera S, Amidror S, Aretz E, Azriel S, Gam Ze Letova C, Naama M, Shoval I, Yaron O, Karako-Lampert S, Bel S and Yissachar N. 
Cell Report
s 2022


The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics

Romina Monzani , Mara Gagliardi, Nausicaa Clemente, Valentina Saverio, Elżbieta Pańczyszyn, Claudio Santoro, Nissan Yissachar, Annalisa Visciglia, Marco Pane, Angela Amoruso, Marco Corazzari 
biology 2022

Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts

Sassone-Corsi M, Azriel S, Simon S, Ramanan D, Ortiz-Lopez A, Chen F, Yissachar N, Mathis D and Benoist C. 

PNAS 2022


An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Azriel S*, Bootz H*, Shemesh A*, Amidror S, Yissachar N.

J Vis Exp. 2021


A Gut-Ex-Vivo System to Study Gut Inflammation Associated to Inflammatory Bowel Disease (IBD)

Gagliardi M, Monzani R, Clemente N, Fusaro L, Saverio V, Grieco G, Pańczyszyn E, Yissachar N, Boccafoschi F, Corazzari M.

Biology 2021


Gut-Ex-Vivo system as a model to study gluten response in celiac disease


Gagliardi M, Clemente N, Monzani R, Fusaro L, Ferrari E, Saverio V, Grieco G, Pańczyszyn E, Carton F, Santoro C, Del Mare-Roumani S, Amidror S, Yissachar N, Boccafoschi F, Zucchelli S, Corazzari M

Cell Death Discov. 2021


High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function


Grosheva I, Zheng D, Levy M, Polansky O, Lichtenstein A, Golani O, Dori-Bachash M, Moresi C, Shapiro H, Del Mare-Roumani S, Valdes-Mas R, He Y, Karbi H, Chen M, Harmelin A, Straussman R, Yissachar N, Elinav E, Geiger B.

Gastroenterology 2020


β-arrestin 2 quenches TLR signaling to facilitate the immune evasion of EPEC.


Chen Z, Zhou R, Zhang Y, Hao D, Wang Y, Huang S, Liu N, Xia C, Yissachar N, Huang F, Chu Y, Yan D.

Gut Microbes 2020


Propionic acid shapes the course of multiple sclerosis by a distinct immunomodulatory mechanism

Duscha A*, Gisevius B*, Hirschberg S*, Yissachar N*, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, and Haghikia A. 

Cell 2020 

* Denotes equal contribution

Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks

Yissachar N.

Curr Opin Neurobiol. 2020


An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk

Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D and Benoist C. 

Cell 2017


This work was recommended by the Faculty of 1000 (2017)

This work was highlighted by Ivanov, Trends in Immunology (2017)

This work was highlighted by Thomas, Nature Reviews Gastroenterology and Hepatology (2017)

Dynamic response diversity of NFAT isoforms in individual living cells.

Yissachar N*, Sharar Fischler T*, Cohen AA, Reich-Zeliger S, Russ D, Shifrut E, Porat Z, Friedman N.

Molecular Cell 2013

* Denotes equal contribution


Chromatin conformation governs T-cell receptor Jβ gene segment usage.

Ndifon W, Gal H, Shifrut E, Aharoni R, Yissachar N, Waysbort N, Reich-Zeliger S, Arnon R, Friedman N. 

Proc Natl Acad Sci U S A 2012


Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.

Salem H*, Rachmin I*, Yissachar N*, Cohen S, Amiel A, Haffner R, Lavi L, Motro B. 

Oncogene 2010

* Denotes equal contribution


Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated.

Noy-Lotan S, Dgany O, Lahmi R, Marcoux N, Krasnov T, Yissachar N, Ginsberg D, Motro B, Resnitzky P, Yaniv I, Kupfer GM, Tamary H. 

Haematologica 2009


Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.

Yissachar N, Salem H, Tennenbaum T, Motro B.

FEBS Lett. 2006


Nek1 shares structural and functional similarities with NIMA kinase


Feige E, Shalom O, Tsuriel S, Yissachar N, Motro B. Biochim Biophys Acta.

Biochimica et Biophysica Acta (BBA) 2006

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