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PUBLICATIONS
Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis
Naim G*, Romano H*, Amidror S*, Jessula Levy D, Cohen A, Sochen C,Yarden Y, Feng M, Farah N, Tsentsarevsky R, Brodie Z, Reich Y, Simon A, Toister E, Shoval I, Mandel Y, Biton M, Yissachar N.
Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome
Colon impairments and inflammation driven by an altered gut microbiota leads to social behavior deficits rescued by hyaluronic acid and celecoxib
Agranyoni O, Sur D, Amidror S, Shidlovsky N, Bagaev A, Yissachar N, Pinhasov A, Navon-Venezia S.
Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics
Bootz-Maoz H, Simon A, Del Mare-Roumani S, Bennet Y , Toister E, Romano H, Zheng D, Amidror S, Elinav E and Yissachar N.
npj biofilms and microbiomes 2023
Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome
Bootz-Maoz H*, Pearl A*, Melzer E*, Malnick S*, Sharon E, Bennet Y, Tsentsarevsky R, Abuchatzera S, Amidror S, Aretz E, Azriel S, Gam Ze Letova C, Naama M, Shoval I, Yaron O, Karako-Lampert S, Bel S and Yissachar N.
Cell Reports 2022
The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics
Monzani R , Gagliardi M, Clemente N, Saverio V, Pańczyszyn E , Santoro C, Yissachar N, Visciglia A, Pane A, Amoruso A, Corazzari A
biology 2022
Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts
Sassone-Corsi M, Azriel S, Simon S, Ramanan D, Ortiz-Lopez A, Chen F, Yissachar N, Mathis D and Benoist C.
An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
A Gut-Ex-Vivo System to Study Gut Inflammation Associated to Inflammatory Bowel Disease (IBD)
Gagliardi M, Monzani R, Clemente N, Fusaro L, Saverio V, Grieco G, Pańczyszyn E, Yissachar N, Boccafoschi F, Corazzari M.
Gut-Ex-Vivo system as a model to study gluten response in celiac disease
Gagliardi M, Clemente N, Monzani R, Fusaro L, Ferrari E, Saverio V, Grieco G, Pańczyszyn E, Carton F, Santoro C, Del Mare-Roumani S, Amidror S, Yissachar N, Boccafoschi F, Zucchelli S, Corazzari M
High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function
Grosheva I, Zheng D, Levy M, Polansky O, Lichtenstein A, Golani O, Dori-Bachash M, Moresi C, Shapiro H, Del Mare-Roumani S, Valdes-Mas R, He Y, Karbi H, Chen M, Harmelin A, Straussman R, Yissachar N, Elinav E, Geiger B.
β-arrestin 2 quenches TLR signaling to facilitate the immune evasion of EPEC.
Chen Z, Zhou R, Zhang Y, Hao D, Wang Y, Huang S, Liu N, Xia C, Yissachar N, Huang F, Chu Y, Yan D.
Propionic acid shapes the course of multiple sclerosis by a distinct immunomodulatory mechanism
Duscha A*, Gisevius B*, Hirschberg S*, Yissachar N*, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, and Haghikia A.
* Denotes equal contribution
Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks
An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk
Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D and Benoist C.
This work was recommended by the Faculty of 1000 (2017)
This work was highlighted by Ivanov, Trends in Immunology (2017)
This work was highlighted by Thomas, Nature Reviews Gastroenterology and Hepatology (2017)
Dynamic response diversity of NFAT isoforms in individual living cells.
Yissachar N*, Sharar Fischler T*, Cohen AA, Reich-Zeliger S, Russ D, Shifrut E, Porat Z, Friedman N.
* Denotes equal contribution
Chromatin conformation governs T-cell receptor Jβ gene segment usage.
Ndifon W, Gal H, Shifrut E, Aharoni R, Yissachar N, Waysbort N, Reich-Zeliger S, Arnon R, Friedman N.
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.
Salem H*, Rachmin I*, Yissachar N*, Cohen S, Amiel A, Haffner R, Lavi L, Motro B.
* Denotes equal contribution
Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated.
Noy-Lotan S, Dgany O, Lahmi R, Marcoux N, Krasnov T, Yissachar N, Ginsberg D, Motro B, Resnitzky P, Yaniv I, Kupfer GM, Tamary H.
Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.
Nek1 shares structural and functional similarities with NIMA kinase
Feige E, Shalom O, Tsuriel S, Yissachar N, Motro B. Biochim Biophys Acta.
Biochimica et Biophysica Acta (BBA) 2006